耐甲氧西林金黄色葡萄球菌的变迁与耐药性分析

Transition and Resistance Analysis of MRSA in Six Years

目的探讨耐甲氧西林金黄色葡萄球菌（MRSA）的流行分布和多药耐药趋势,防止MRSA的上升,采取有效的医院管理措施。方法对2003-2008年医院住院患者部分门诊患者各类标本分离到的金黄色葡萄球菌作药敏试验和甲氧西林耐药性测定。结果 6年中MRSA分离率分别为56.8%、79.6%、52.9%、17.8%、20.2%、12.9%,对大部分临床常用抗菌药物耐药率随MRSA的变化而变化,利福平耐药率较低,未发现耐万古霉素金黄色葡萄球菌。结论医院MRSA分离率2003-2005年与高发地区相近,2006-2008年明显下降。

OBJECTIVE To investigate the prevalence of meticillin-resistant Staphylococcus aureus（MRSA） distribution and trends of multi-drug resistance,prevent the rise of MRSA,and take effective measures of the hospital management.METHODS Antimicrobial susceptibility testing and determination of meticillin resistance of all types of S.aureus isolated from outpatients of the hospital were conducted during from 2003 to 2008.RESULTS The isolation rate of meticillin-resistant S.aureus during the 6 years were 56.8%,79.6%,52.9%,17.8%,20.2%,and 12.9% and they were resistant to almost all commonly used clinical antibiotics in pararell with the changes of MRSA,the resistance rate to rifampicin was low,and no vancomycin-resistant S.aureus was found.CONCLUSIONS The isolation rate of MRSA in our hospital in 2003-2005 is similar with the high incidence area,but it decreaseds obviously in 2006-2008.