脑脊液6项指标检测对脑膜炎的诊断价值

Diagnostic Value of Detection of Cerebrospinal Fluid for Meningitis

目的探讨脑脊液中糖(GLU)、乳酸脱氢酶(LDH)、腺苷脱氢酶(ADA)、IgA、IgG、Ig M等6项指标联合检测在脑膜炎中的应用价值。方法检测3种脑膜炎的脑脊液中GLU、LDH、ADA、IgA、IgG、Ig M的含量,并与对照组进行比较分析。结果化脓性脑膜炎组和结核性脑膜炎组中的GLU显著低于病毒性脑膜炎组和对照组;化脓性脑膜炎组和结核性脑膜炎组中的LDH显著高于病毒性脑膜炎组和对照组;结核性脑膜炎组中的ADA显著高于另外3组;化脓性脑膜炎组和结核性脑膜炎组中IgA、IgG和Ig M的含量显著高于病毒性脑膜炎组和对照组;化脓性脑膜炎组中的Ig M升高最显著,结核性脑膜炎组中的IgA、IgG升高最显著(P<0.01)。结论脑脊液中GLU、LDH、ADA、IgA、IgG、Ig M检测在脑膜炎的鉴别诊断中有很高的参考价值。

OBJECTIVE To study the clinical value of detection GLU,lactic dehydrogenase（LDH）,adenosine deaminase（ADA） and immunoglobu-lins IgA,IgG and IgM in cerebrospinal fluid（CSF） for meningitis.METHODS GLU、LDH、ADA、IgA、IgG and IgM in CSF were detect in three type meningitis,and compared with the control group.RESULTS The level of GLU in the patients with purulent meningitis and tuberculous meningitis was significantly lower than that in other two groups,the level of LDH in the patients with purulent meningitis and tuberculous meningitis was significantly higher than that in other two groups,the level of ADA in the patients with tuberculous meningitis was significantly higher than that in other three groups,The levels of IgA、IgG and IgM in the patients with purulent meningitis and tuberculous meningitis were significantly higher than that in other two groups,The level of IgM in the patients with purulent meningitis was significantly higher than that in other three groups,the levels of IgA and IgG in the patients with tuberculous meningitis were significantly higher than that in other three groups（P〈0.01）.CONCLUSIONS It has high referenced value to distinguish and diagnose the meningitis of detect the levels of GLU、LDH、ADA、IgA、IgG and IgM in CSF.