重症监护病房铜绿假单胞菌耐药性分析及对策

Drug Resistance of Pseudomonas aeruginosa in Intensive Care Unit of Our Hospital:Analysis and Strategy

目的分析医院重症监护病房铜绿假单胞菌的耐药情况,为降低铜绿假单胞菌耐药提供对策。方法采集2008年4月～2009年5月入住重症监护病房患者的各类标本进行细菌学培养、鉴定及药敏试验,选择抗菌药物,同时观察疗效。结果医院重症监护病房铜绿假单胞菌耐药情况严重,134株铜绿假单胞菌中多药耐药菌株占31.3%,泛耐药株占4.5%;经验用药有效率为57.5%,根据药敏试验结果选择抗菌药物,有效率为80.4%。结论铜绿假单胞菌易产生多药耐药,治疗比较困难,应以预防为主,加强耐药菌株监测,尽早进行药敏试验,合理使用抗菌药物,延缓其耐药菌株的产生,降低耐药菌株的感染率。

OBJECTIVE To investigated the drug resistance of Pseudomonas areuginosa in intensive care unit（ICU）of our hospital in order to provide more evidence for clinical rational drug utilization..METHODS Clinical samples were collected from patients in ICU from Apr 2008 to May 2009.Then,bacterial culture,general identification and susceptibility test were performed.Antimicrobial agents were selected,and the curative effects were analyzed.RESULTS Drug resistance of P.areuginosa was severe in ICU of our hospital.In 134 studied strains of P.areuginosa,multiresistant bacteria and pandrug-resistant bacteria accounted for 31.3% and 4.5%,respectively.The efficacy rate of the drug based on experiences or susceptibility test was 57.5% and 80.4%,respectively.CONCLUSIONS P.aeruginosa can easily produce multidrug resistance,which is difficult to manage.Therefore,a series of measures,including prevention first and strengthening resistance monitoring and susceptibility test should be done.Rational selection of antibiotics is very important for reducing the generation of drug resistant strains and decreasing the incidence of hospital infection.