深静脉血栓形成与凝血因子Ⅷ及蛋白C、蛋白S的相关性

Relationship between factor Ⅷ, protein C, protein S and lower deep venous thrombosis

目的检测下肢深静脉血栓形成的患者血浆中凝血因子Ⅷ（FⅧ）及蛋白C、蛋白s水平的变化，探讨其与深静脉血栓形成的关系。方法用ACLTOP型全自动血凝分析仪检测40例急性期深静脉血栓形成患者及40例健康体检者血浆中FⅧ及蛋白C、蛋白S的活性。结果与正常对照组比较，病例组患者体内FⅧ的活性明显增高，是深静脉血栓形成的危险因素，OR值为11．0，95％可信区间为3．3～36．7，排除蛋白C、蛋白S降低的影响，则OR值为5．4，95％可信区间为1．6～18．2。两组比较，病例组中蛋白C和蛋白S的活性明显降低，差异有统计学意义（P〈0．05）。结论深静脉血栓形成的患者体内FⅧ活性明显升高，而蛋白C及蛋白S的活性明显降低，凝血及抗凝系统的异常是深静脉廊栓形成的高危因素之一。

Objective To detect the activity of plasma factorⅧ, protein C, protein S in patients with lower deep venous thrombosis. Methods American IL automatic analyzer was used to detect the activity of factor Ⅷ, protein C and protein S in 40 patients with deep venous thrombosis and 40 normal controls. Results The plasma level of factor Ⅷ was statistically significantly higher in the study group than in the control group （P 〈 0. 05 ）. Factor Ⅷ was associated with an increased risk of venous thrombosis with the relative risk being 11.0 （95% CI, 3.3-36. 7）. Excluding the patients with reduced protein C and pro- tein S levels, the relative risk was dropped to 5.4 （95% CI, 1.6-18.2）. There also were significant differences in the activity of protein C, protein S between the study group and the normal control group （P 〈 O. 05）. Conclusion The activity of factor Ⅷ in patients with deep venous thrombosis is increased significantly, and the activity of protein C, protein S decreased obviously. All of those are risk factors for deep venous thrombosis.