摘要
目的研究一种固体二氧化氯消毒剂杀菌效果及其毒性。方法用悬液定量杀菌试验和动物毒性试验方法进行了实验室观察。结果用含30mg/L该固体二氧化氯的溶液对悬液内大肠杆菌、铜绿假单胞菌作用5min,平均杀灭对数值>5.00;对金黄色葡萄球菌作用10min,平均杀灭对数值>5.00;对白色念珠菌作用15min,平均杀灭对数值>5.00。用含30mg/L该固体二氧化氯溶液浸泡黄瓜10min,对其表面污染的大肠杆菌平均杀灭对数值为3.30;对木质桌面擦拭2遍并作用10min,对其表面自然菌可达到消毒合格指标。该固体二氧化氯在使用浓度5倍对小鼠急性经口毒性LD50値>5000mg/kg(体重),小鼠骨髓嗜多染红细胞微核试验阴性。结论该固体二氧化氯对细菌繁殖体和真菌杀菌效果较强,毒性低。
Objective To observe the germicidal efficacy and toxicity of a solid chlorine dioxide disinfectant. Methods Suspension quantitative germicidal tests and toxicity tests were conducted. Results The average killing logarithm values of Escherichia coli and Pseudomonas aeruginosa exposed to the solution containing 30 mg/L chlorine dioxide for 5 min were 5.00. The value of Staphylococcus aureus exposed for 10 min was 5.00 ; the value of Candida albicans exposed for 15 min was 5.00. For the same solution,the average killing logarithm value of E. coli contaminated on cucumber was 3.30 with soaking for 10 min. The qualified disinfection rate of natural bacteria on wooden table surface could be obtained after wiping twice with the solution and contact for 10 min. Toxicity tests showed that the LD50 of solution with 5-fold of applicable concentration was 5 000 mg/kg·bw in acute oral toxicity test in mice. Result of micronucleus test in mice marrow polychromatophilic erythrocyte was negative. Conclusion This disinfectant has good germicidal efficacy and low toxicity.
出处
《中国消毒学杂志》
CAS
2010年第3期283-285,共3页
Chinese Journal of Disinfection
关键词
二氧化氯
固体制剂
杀菌效果
毒性
chlorine dioxide
solid preparation
germicidal efficacy
toxicity
