摘要
目的观察急性心肌梗塞（ＡＭＩ）患者接受静脉溶栓治疗时，血清肌钙蛋白Ⅰ（ｃＴｎⅠ）浓度变化，探讨其对溶栓疗效的判定价值。方法选择ＡＭＩ患者５３例，２６例接受溶栓治疗。采用ＯＰＵＳ自动生化分析仪，以ＥＬＩＳＡ法测定ｃＴｎⅠ浓度。结果显示：（１）从发病到达ｃＴｎⅠ峰值时间，２２例溶栓再通组（１５．７±３．９小时）比４例溶栓未通组（２２．０±２．３１小时）及２７例未溶栓组（２６．２±１１．１小时）均明显提前（Ｐ＜０．０５）。（２）血清ｃＴｎⅠ峰值水平在溶栓再通组（３２８．０±２４５．２μｇ／Ｌ）比溶栓未通组（１７０．５±５０．２μｇ／Ｌ）及未溶栓组（１３０．７３±１００．０３μｇ／Ｌ）明显增高（Ｐ＜０．０１）。（３）以ｃＴｎⅠ峰值到达时间≤１８小时判定ＡＭＩ后溶栓再通，其敏感性、准确性（分别为７２．７％和７３．１％），均高于ＣＫ－ＭＢ≤１４小时（分别为６３．６％和６５．４％），特异性二者相同（均为７５％）。结论血清ｃＴｎⅠ水平，在ＡＭＩ溶栓再通患者中峰值时间前移，其≤１８小时对ＡＭＩ溶栓再通具有一定的判定价值。
Objective To observe the changes of serum cardiac troponin (cTn) levels in patients
with acute myocardial infarction (AMI),and judge its predictive value on the effect of
thrombolysis Methods 53 cases of AMI patients were selected,of which 26 cases receiving
intravenous thrombolysis Results (1) The time from AMI onset to the cTn peak was earlier in 22
cases of reperfusion (1507390) than both 4 cases of nonreperfusion (220231) and 27 cases of
not receiving thrombolysis (26171114,all P<005)(2) The peak level of cTn was significantly
higher in the reperfusion group (3280324524) than in nonreperfusion group (170505021) as well
as in group not treated by thrombolysis (1307310003,all P<001)(3) As to predicting the
reperfusion after thrombolysis,the sensitivity,specificity and accuracy were 727%,75% and
731% respectively for the time of cTn peak18 h,while 636%,75% and 654% respectively for the
time of CKMB peak14 h ConclusionThe time from AMI onset to the serum cTn peak level is
shorter in AMI cases of reperfusion after thrombolysis,and has definite predictive value on the
effect of intravenous thrombolysis when it is 18 h
出处
《中国介入心脏病学杂志》
1999年第1期11-13,共3页
Chinese Journal of Interventional Cardiology
