新生儿坏死性小肠结肠炎危险因素分析

Analysis on the risk factors which cause neonatal necrotizing enterocolitis

目的探讨新生儿坏死性小肠结肠炎(NEC)的危险因素及其在NEC发病中起到的作用。方法 2003年1月至2007年12月在广州医学院第三附属医院新生儿科住院确诊为NEC的32例患儿为病例组,同期在本院产科出生的32例健康新生儿为对照组。归纳出可能引起NEC的早产、窒息、孕高征等19个疑似危险因素,用SPSS13.0软件进行Logistic回归分析。通过Logistic分析,筛选出有统计学意义的危险因素。结果最终筛选出NEC的危险因素有3个,分别为早产、窒息、非母乳喂养因素,其他因素被回归方程排除。OR值分别为:19.474、12.966和16.245。结论本次回归分析显示,早产因素在三者中的OR值最高达19.474,引起NEC的风险最大。但母亲的孕期健康状况作为一个间接诱因也不能忽视。因此做好围产期保健,减少早产儿及低体重儿的出生,防止窒息的发生,提倡母乳喂养是预防NEC的关键。

Objective To explore the risk factors of NEC and the function of these factors in the NEC.Methods 32 hospital neonatal who were diagnosed as NEC during January 2003 to December 2007 were selected as the case group,while 32 healthy babies who were born in the same duration were selected as the control group.Conclude the 19 uncertain risk factors for the NEC about premature labor,asphyxia and Pregnancy-induced Hypertension et al,use Logistic regression to analyze the data above by the software of SPSS 13.0,screen out the risk factors which have statistical signification.Results There are three risk factors of statistical significant which were selected.They are premature labor,asphyxia and non-breast feeding respectively.The other factors were excluded by the Logistic regression equation.The result of OR is respectively 19.474,12.96 and 16.245.Conclusion The data shows the OR value of premature labor is the highest in the three risk factors,but we cann’t neglect the Pregnant disease and the other factors.Pregnant disease is maybe a indirect factor for the NEC.Thereby,the keys of prevention NEC are reducing the incidence rate of the premature delivery and asphyxia,controing infection and feed baby in correct way.