尼美舒利与布洛芬治疗高热患儿疗效比较

Curative comparison of therapy heperpyrexia patient of children with nimesulide and ibuprofen

目的对非甾体类解热镇痛药尼美舒利颗粒、布洛芬混悬液治疗高热患儿效果和不良反应的比较。方法选择1～13岁的高热患儿120例,随机分为两组,在常规治疗基础上,一组使用尼美舒利颗粒口服3mg/kg,另一组使用布洛芬混悬液口服5mg/kg。测定治疗前、治疗后30min、1h、2h、6h体温,并观察疗效及不良反应。结果尼美舒利组在1h内体温下降幅度比布洛芬组大,而且维持时间长。结论口服尼美舒利颗粒治疗高热患儿较布洛芬混悬液起效快,不良反应小,使用较安全,临床上值得推广使用。

Objective To compare effect therapy heperpyrexia patient of children with nimesulide granule and ibuprofen oral infusion for the use of non-streroidal antipyretic analgesics.Methods Ranging in age from 1 to 13 years,randomization divide into both groups,in a foundation of conventional therapy one groups make use Nimesulide 3 mg/kg,use ibuprofen 5 mg/kg as therapy of other groups.respectively determination body temperature before and after of in the therapy of 30 min、1 h、2 h、6 h and watch over curative as well as abverse reaction.Results Nimesulid granule not only larger than ibuprofen oral infusion within one hour cause body temeperature fall down range but also long maintenance time.Conclusion Compare nimesulide granule with ibuprofen oral infusion,act on to reduce fever is of rapid more minor obverst reaction and be able to use of safety,on clinical therapy is to be merites popularization.