己酮可可碱治疗急性呼吸窘迫综合征疗效观察

Clinical observation of Pentoxifylline combined with mechanical ventilation in acute respiratory distress syndrome

目的探讨己酮可可碱联合机械通气治疗急性呼吸窘迫综合征（ARDS）的临床疗效。方法将64例ARDS患者随机分为对照组和己酮可可碱组（PTX组）各32例。对照组采用常规治疗，PTX组患者在此基础上加用己酮可可碱注射液200mg，每日2次。观察两组患者治疗效果、血气分析指标及血清中肿瘤坏死因子α（TNF-α）、白细胞介素8（IL-8）含量变化。结果治疗后3、7d两组患者动脉血氧分压（PaO2）、氧合指数（PaO2／FiO2）差异有统计学意义（P〈0．05），PTX组血清TNF—α、IL-8及病死率均低于对照组（P〈0．05）。结论PTX联合机械通气治疗能够有效阻抑ARDS患者的炎性反应，改善患者氧合情况和预后。

Objective To explorer the clinical effects of Pentoxifylline（ PTX group） with mechanical ventilation in patients with acute respiratory distress syndrome（ARDS）. Methods 64 patients with ARDS were randomized into a control group（n =32,ARDS conventional treatment） and a PTX group（n =32,PTX 50ml iv bid in addition to the conventional treatment）. The patients were closely monitored with their curative effect, blood gas indexes and serum levels of TNF-α and IL-8 after the treatment. Results The PaO2 and PaO2/FiO2 got significantly higher in the PTX group than in the control group on 3d and 7d（ P 〈 0. 05 ）. The serum levels of TNF-α and IL-8 and the mortality of ARDS were significantly decreased in the PTX group after the combined with Pentoxifylline （ P 〈 0. 05 or P 〈 0. 01）. Conclusion The treatment combined with the Pentoxifylline can effectively improve the Oxygenation and prognosis of ARDS patients by inhibiting the inflammatory responses.