维持性血液透析患者钙磷代谢紊乱分析

Analysis of calcium-phosphorus metabolism disorder in maintenance hemodialysis patients

目的分析维持性血液透析患者钙磷代谢紊乱情况。方法对70例维持性血液透析患者的钙、磷浓度、钙磷浓度乘积及甲状旁腺素（PTH）进行测定，并与K／DOQI指南指标进行比较。结果70例患者中，≥50岁36例，〈50岁34例，两组血清钙、磷浓度及钙磷乘积、PTH水平比较，差异均无统计学意义（均P〉0．05）；透析时间越长，患者血清磷、PTH水平改变越明显，差异有统计学意义（均P〈0．05）；70例中有46例（65．7％）血清钙、34例（48．6％）血清磷、40例（57．1％）钙磷乘积、28例（40％）PTH浓度达到K／DOQI指南要求，仅有18例（25．7％）患者所有指标达到K／DOQI要求。结论多数血液透析患者钙磷代谢控制仍然达不到K／DOQI要求的目标。

Objective To analyze the disorder status of calcium-phosphorus metablism in maintenance hemodialysis patients. Methods Serum calcium, serum phosphorus, calcium-phosphorus product and PTH were detected in 70 patients with maintenance hemodialysis, and compared with the indicators of K/DOQI guidelines. Results There were 36 cases over 50 years age and 34 cases less than 50 years age in 70 cases, and there were no significant differences in serum calcium, serum phosphorus, calcium-phosphorus product and PTH between two groups （P 〉 0. 05 ）. The longer the dialysis, the more obvious changes of serum phosphorus and PTH levels, and there were significant differences （P 〈 0. 05 ）. In 70 cases ,46 cases （65.7%） serum calcium ,34 cases （48.6%） serum phosphorus ,40 cases（57. 1% ） calcium and phosphorus product ,28 cases（ 40% ） PTH met the requirement of K/DOQI guidelines, only 18 cases（25.7% ） of all indicators reached the K/DOQI requirements. Conclusion The calcium-phosphorus metablism in most hemodialytic patients still cannot reach the K/DOQI guidelines.