卡托普利联合甲泼尼龙治疗难治型肾病综合征疗效观察

The efficacy of captopril combined with methylprednisolone for treatment of RNS

目的 探讨卡托普利联合甲泼尼龙冲击治疗难治型肾病综合征的疗效。方法选择21例难治型肾病综合征患儿，给予口服卡托普利1．25mg／d，静脉滴注甲泼尼龙治疗剂量为20mg·kg^-1·d^-1，加入5％葡萄糖注射液100～200ml中，于1—2h内静脉滴注，连用3d为1个疗程，如未缓解，1周后可重复。结果21例患儿中完全缓解13例，部分缓解5例，未缓解3例，总缓解率为86％。在完全缓解的13例中，4例在2疗程后缓解，5例在4疗程后缓解，4例在6疗程后缓解。结论卡托普利联合甲泼尼龙冲击治疗可提高难治型肾病综合征缓解率。

Objective To explore the efficacy of captopril and methylprednisolone in the implosive therapy of RNS. Methods 21 cases of RNS who have captopril 1.25 mg/d and intravenous dripping methylprednisolone of 20 mg/kg· d sustained 1-2h for 3 days,if non-remissions,using once more after a week. Results 21 cases of children with complete remission in 13 cases, partial remission in 5 cases, non-remission in 3 cases. The overall response rate was 86%. In complete remission 13 eases,4 cases remission after 2 courses treatment, 5 cases remission after four courses treatment,4 cases remission after 6 courses treatment, Conclusion Combined captopril with methylprednisolone in treating refractory nephritic syndrome can improve the rate of remission.