异维A酸胶丸联合清肝祛痤方治疗囊肿聚合性痤疮的临床观察

Treatment of Cyst Jialing River Acne with Isotretinoin Soft Capsule Combined with Qing-gan Qu-cuo Recipe

目的:观察和研究异维A酸胶丸(泰尔丝)联合清肝祛痤方治疗囊肿聚合性痤疮的临床疗效。方法:50例囊肿聚合性痤疮患者随机分为两组,均给予异维A酸胶丸(泰尔丝)每次20mg,每天2次口服。治疗组(n=30)在此基础上加用清肝祛痤方,每日1剂,早晚分服,于治疗初始和2,4,8周时观察评价皮损改善,不良反应及16周时的复发情况。结果:治疗组有效率90.0%,对照组有效率45.0%。治疗组总皮损均数、炎症性皮损均数、非炎症性皮损均数治疗8周后与治疗前比较,差异有统计学意义(P<0.05或P<0.01)。对照组总皮损均数、炎症性皮损均数治疗8周后与治疗前比较,差异有统计学意义(P<0.05或P<0.01),非炎症性皮损均数治疗8周后与治疗前比较,差异无统计学意义(P>0.05)。治疗组治疗8周后总皮损均数、非炎症性皮损均数与对照组相比较,差异有统计学意义(P<0.05或P<0.01),炎症性皮损均数治疗后两组比较差异无显著性(P>0.05)。结论:异维A酸胶丸联合清肝祛痤方治疗囊肿聚合性痤疮疗效肯定,复发率低且不良反应少。

Objective：To observe and study Isotretinoin soft capsules （TaiErSi） combined with Qing-gan Qu-cuo recipe in treating cyst jialing river acne. Method：50 patients cyst jialing river acne patients were randomly divided into two groups,Isotretinoin soft capsules （TaiErSi） 20mg,2 times every day. The treatment group （ n = 30） was added with qing-gan qu-cuo recipe daily. In the treatment of initial and 2,4,8 weeks,observing and studying the lesions＇ recovery,assessing skin evaluation for 16 weeks and adverse reaction of recurrence. Result： The efficiency of treatment group and control group was 90. 0% vs 45. 0% . Total skin lesions means,inflammatory lesions means and noninflammatory lesions means of treatment group 8 weeks after treatment with before treatment, were statistically significant difference （P 0. 05 or P 0. 01）. The control group＇s total skin lesions means and inflammatory skin lesions means of 8 weeks after treatment compared with before treatment were statistically significant differente （P 0. 05 or P 0. 01）,the noninflammatory lesions means of control group before and after treatment were no significant differente （ P 0. 05 ）. 8 weeks after treatment,total skin lesions means and noninflammatory skin lesions means of treatment group are better than those of control group significantly（P 0. 05 or P 0. 01）,the inflammatory lesions means of both groups 8 weeks after treatment were no statistically significant difference between the two groups （P 0. 05）. Conclusion：Isotretinoin soft capsules combined with qing-gan qucuo recipe in treating Cyst jialing river acne has reliable effect,low recurrent rate and less adverse reactions.