育龄期多囊卵巢综合征患者的糖代谢异常和胰岛素抵抗

The correlation between glucose metabolism and insulin resistance in the adult women with polycystic ovary syndrome

目的探讨育龄期多囊卵巢综合征（PCOS）患者的糖代谢异常和胰岛素抵抗。方法选择育龄期PCOS患者168例，分为肥胖PCOS组78例和非肥胖PCOS组90例，正常对照组100例，对比临床表现及检测内分泌激素、空腹血糖、空腹胰岛素、服糖后2h血糖及2h胰岛素。结果育龄期PCOS患者的月经周期、多毛、痤疮、B超提示卵巢增大、卵巢多囊性改变、有不孕史与对照组比较，差异均有显著性（P〈0．05），育龄期PCOS组的血清LH、T与对照组比较，差异有显著性（P〈0．05）。育龄期肥胖P-COS组的空腹血糖、服糖后2h血糖、空腹胰岛素、服糖后2h胰岛素与对照组比较，差异均有显著性（P〈0．05）。结论早期出现月经稀发、BMI升高的患者是否存在PCOS，值得重视。育龄期PCOS患者尤其肥胖型要高度重视糖代谢异常及胰岛素抵抗，以决定是否采取干预措施，避免出现远期并发症而对PCOS患者造成健康威胁。

Objective To investigate glucose metabolism and insulin resistance in the adult women with polycystie ovary syndrome （PCOS）. Methods Seventy-eight cases of obese women with PCOS, ninety ea- ses of non-obese women with PCOS and one hundred cases of control group were reviewed regarding clinical features, endocrinal hormone, fasting glucose, fasting insulin, 2 h postprandial glucose and 2 h postprandial insulin. Results The menstrual cycle, Hirsutism, acne, ultrasonography suggested ovarian increase, polycystic ovary change and infertility of adult women with PCOS were significantly different compared with the control group（ P 〈 0. 05 ）. And the fasting glucose, 2 h postprandial glucose, fasting insulin ,2 h postprandial insulin of the obese group were also significantly higher compared with the control group（P 〈 0. 05 ）. Conclusion Attention would be paid to patients with early oligomenorrhea and high BMI for PCOS diagnosis. Adult women with PCOS especially the obese should check abnormal glucose metabolism and insulin resistance to determine whether actions should be taken to avoid the menace of long term complication.