血尿酸与冠心病的相关性及对血小板聚集功能的影响

The correlation with coronary heart diaease and effects on platelet aggregation function of serum uric acid

目的探讨血尿酸与冠心病的相关性及尿酸水平的变化对血小板聚集功能的影响。方法将120例疑诊为冠心病的患者根据冠状动脉造影结果分为冠心病组（85例）和正常对照组（35例），比较两组间尿酸水平及血小板最大聚集率（MPAR）的差异。同时对冠心病伴高尿酸血症患者进行别嘌醇干预治疗4周，对比分析用药前后尿酸水平及血小板最大聚集率的变化。结果冠心病组血尿酸、MPAR水平显著高于对照组（P〈0．05），单因素相关分析发现冠心病组血尿酸水平与血小板聚集率呈正相关关系（r=0．598，P〈0．05），冠心病伴高尿酸血症患者服药后血尿酸、MPAR水平显著低于服药前（P〈0．05），差别均有统计学意义。结论尿酸可激活血小板，促进血小板的粘附、聚集和释放。

Objective To discuss the correlation with coronary heart diaease and effects on platelet ag- gregation function of serum uric acid（SUA）. Methods 120 patients diagnosed as suspected coronary heart dis- ease were divided into two groups coronary heart diaease group（85cases） and normal control group （35 cases）ac- cording to coronary angiography. Comparing the differences of SUA level and Maximum platelet aggregation rate （MPAR）. Besides, the coronary heart disease with high SUA patients were interfered with allopurinol for 4 weeks. Analysing the changes of SUA level and MPAR before and after treatment. Results The SUA level and MPAR of the former group were significantly higher（ P 〈 0. 05 ）than the latter group. Single-factor correlation a- nalysis showed that uric acid levels and platelet aggregation rate were positively correlated （ r = 0. 598, P 〈 0. 05 ） in coronary heart disease group. The SUA level and MPAR of coronary heart disease patients with hyperu- ricemia taking medicie were significantly lower than before treatment（ P 〈 0. 05 ）. The differences were statisti- cally significant. Conclusion SUA can activate platelets and promote platelet adhesion, aggregation and release and was an important risk factor in the formation and development of coronary heart disease.