低浓度丝裂霉素C与曲安奈德治疗瘢痕疙瘩的应用观察

The therapy function of low concentration mitomycin C associate with steroid to keloid

目的观察低浓度丝裂霉素C与糖皮质激素联合局部注射治疗瘢痕疙瘩的疗效及安全性。方法研究分两组，单纯激素治疗组48例瘢痕疙瘩患者进行单纯曲安奈德注射瘢痕内注射，1次／2周。联合治疗组42例瘢痕疙瘩患者将0．04mg丝裂霉素C与5ml曲安奈德、1ml2％利多卡因混合后局部注射于瘢痕全层，1次／2～4周。瘢痕完全萎缩后逐渐降低药物浓度并延长注射间歇期。结果在治疗6个月以上的患者中，丝裂霉素c联合糖皮质激素治疗瘢痕疙瘩的总有效率为97．62％，其中完全缓解者占45．23％，极大缓解者占47．62％，部分缓解者占4．72％，未缓解者为2．38％。结论低浓度丝裂霉素C与糖皮质激素联合局部注射治疗瘢痕疙瘩的疗效显著。

Objective To monitor the therapeutic action and security of mitomyein C associate with steroid injected to keloid. Methods 48 patients were treated merely with eortieosteroid injection to keloid, once in 2weeks. The other 42 patients around sternal area were treated with intralesional injection of a mixture of 0. 04 mg mitomycin C ,5 ml eortieosteroid and 1 ml 2% lidocaine once per 2-4 weeks. After keloid r became flattened, drug concentration was deereased with prolonged intermission of drug injection. Results＇ The total therapy effi- cacy of mitomyein C associate with steroid to keloid was 97.62%. the complete remission percentage was 45.23%, the large remission percentage was 47.62%, part remission percentage was 4.72%, and the inefficacy percentage was 2. 38%. Conclusion It is more effective that the combination therapy to keloid of low concen- tration mitomvcin C and steroid.