细胞外基质金属蛋白酶诱导因子和血管内皮生成因子-C在乳腺癌的表达及其意义

Expression and significance of EMMPRIN and VEGF-C of breast carcinoma

目的 研究细胞外基质金属蛋白酶诱导因子（EMMPRIN）和血管内皮生成因子-C（VEGF-C）蛋白表达与乳腺癌浸润和转移之间的关系.方法 免疫组化法检测乳腺增生组21例、导管内癌组10例、浸润性导管癌组68例病灶内EMMPRIN和VEGF-C蛋白的表达情况.结果 EMMPRIN蛋白在增生组、导管内癌组、浸润性导管癌组表达阳性率分别为4.76%（1/21）、40.00%（4/10）73.53%（50/68）,3组之间的阳性率差异均有统计学意义（P〈0.01）.VEGF-C蛋白在增生组、导管内癌组、浸润性导管癌组表达阳性率分别为14.29%（3/21）、60.00（6/10）、77.94%（53/68）,导管内癌组和浸润性导管癌组阳性率明显高于增生组（P〈0.01）.乳腺癌组织中EMMPRIN和VEGF-C的表达呈正相关（rs=0.390,P〈0.01）,而且EMMPRIN和VEGF-C的表达与腋窝淋巴结转移及淋巴结转移数目有关（P〈0.01）.结论 EMMPRIN和VEGF-C的过度表达是促进乳腺癌浸润和转移的重要因素,二者在乳腺癌的浸润和转移过程中可能起着协同作用.

Objective To study the correlation of EMMPRIN and VEGF-C expression with invasion and metastasis of breast carcinoma. Method The expression of EMMPRIN and VEGF-C was detected by immunohistochemical technique in 21 cases hyperplasia of mammary glands, 10 cases of in-tubule carcinoma and 68 cases invasive carcinoma. Results The positive rate of EMMPRIN expression in hyperplasia of mammary glands, in-tubule carcinoma and invasive carcinoma were 4. 76% （1/21）, 40. 00% （4/10）73.53% （50/68）, respectively;Significant difference was found among three groups （ P 〈 0.01 ）. The positive rate of VEGF-C expression in hyperplasia, in-tubule carcinoma and invasive carcinoma were14. 29% （3/21） ,60. 00 （6/10） ,77.94% （53/68）, respectively. The positive rates of VEGF-C expression in situ and invasive ductal carcinoma were remarkably higher than that of hyperplasia of mammary glands （ P 〈0. 01 ）. The expression of EMMPRIN significantly correlated with the expression of VEGF-C in breast tubule carcinoma （ rs =0. 390, P 〈0. 01 ）, Lymph nod metastasis and the number axillary Lymph nod metastasis were related to EMMPRIN and VEGF-C （ P 〈 0. 01 ）. Conclusion The over-expression of EMMPRIN and VEGF-C were important elements to promote the invasiveness and metastasis of breast carcinoma. Synergistic effect between EMMPRIN and VEGF-C may take place in lymph node metastasis of breast carcinoma.