摘要
目的:探讨人类刺猬因子SHH(Sonic hedgehog)的表达与胃癌(Gastric carcinoma)临床病理特征的关系及其临床意义。方法:应用免疫组织化学SP法,检测60例胃癌组织标本中SHH的表达情况,分析其与临床病理特征的关系。结果:胃癌组织中SHH阳性表达率为68.3%(41/60)。SHH阳性表达与浸润深度、淋巴结转移、TNM分期相关(P<0.05)。结论:SHH蛋白在胃癌中表达升高,并与胃癌发生、分期及淋巴结转移有关,或可作为胃癌预后判断指标及潜在的治疗靶点。
Objective：To investigate the expression of sonic hedgehog（SHH） in gastric cancer,analyze the relationship with clinic pathological features,and discuss the clinical significance.Methods：Immunohistochemistry SP method was used to detect the expression of SHH in 60 cases of gastric cancer,and the relationship between protein expression and clinic pathological features was analyzed.Results：The positive expression rates of SHH was 68.3%（41/60）in gastric cancer.The expression rates of SHH was correlated with depth of invasion,lymph node metastasis,and TNM stage（P0.05）.Conclusion：The expression of SHH increased in gastric cancer and has correlation with gastric carcinogenesis,staging and lymph node metastasis.SHH might be the prognostic marker and potential therapeutic target for gastric cancer.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2010年第3期372-374,共3页
Journal of Chongqing Medical University
关键词
胃癌
免疫组织化学
SHH
治疗
Gastric cancer
Sonic hedgehog（SHH）
Immunohistochemistry
Therapeutics
