粉尘螨滴剂对螨性过敏性紫癜患儿的疗效

Curative Effect of Dermatophagoides Farinae Drops on Children with Henoch-Schonlein Purpura Allergic to Dust Mite

目的探讨粉尘螨滴剂对螨性过敏性紫癜(HSP)患儿的疗效及预后的影响。方法选择2005年10月-2007年10月在本院儿科门诊与病房治疗的2～15岁粉尘螨、屋尘螨呈阳性患儿100例,随机分为对照组和试验组,每组50例。对照组应用常规治疗(激素、维生素C、复方芦丁片、氯雷他定片);试验组在常规治疗的基础上再加用粉尘螨滴剂舌下含服治疗,从低剂量起逐步递增,每天1次,治疗1a,随访1a。采用SPSS11.4软件进行统计学分析。结果对照组和试验组患儿均无脱落病例,粉尘螨滴剂干预1a后2组患儿复发次数比较差异有统计学意义(P<0.01)。干预前2组患儿血清IgE、24h尿蛋白定量及高倍镜下尿红细胞数比较差异均无统计学意义(Pa>0.05),干预后2组患儿血清IgE、24h尿蛋白定量及高倍镜下尿红细胞数比较差异均有统计学意义(Pa<0.05)。结论舌下含服粉尘螨滴剂能有效减少儿童螨性HSP的复发,降低其肾脏损害的发生率,改善预后。

Objective To explore the curative effect of dennatophagoides farinae drops on children with Henoeh - Sehonlein purpura （HSP） allergic to dust mite and the influence on prognosis. Methods One hundred HSP children （2 - 15 years old ） allergic to dust mite were divided randomly into intervention group （ n = 50） and control group （ n = 50 ）. Both groups were given the traditional treatment （ steroid, vitamin C ,compound rutin tablets,loratadine tablets）. And dermatophagoides farinae drops were added to the intervention group by sublingual administration from low dosage to high dosage. The children were followed up for 1 year. The data were analyzed by SPSS 11.4 software. Results All cases were followed up during the period. After intervention , there was significant difference in relapse between 2 groups （ P 〈 0.01 ）. Before intervention, there was no significant difference in serum IgE, 24 hour proteinuria, urine red cell count in HSP between 2 groups （P〉 0.05）. After intervention, there was significant difference in serum lgE, 24 hour proteinuria, urine red cell count in HSP between 2 groups（P 〈0.05）. Conclusions Dermatophagoides farinae drops has satisfactory efficacy in reducing relapse, kidney damage and improving prognosis in HSP children.