原发性皮肤间变性大细胞淋巴瘤14例病理和临床分析

A study of 14 primary cutaneous anaplastic large cell lymphoma cases into their pathology features and relevance with clinical manifestations

目的总结原发性皮肤间变性大细胞淋巴瘤（PC—ALCL）的病理形态学、免疫表型、临床表现等特点，提高对该病的认识。方法回顾性分析14例PC-ALCL的形态学、免疫表型、临床表现等资料，总结它们的特点。结果14例PC—ALCL中，随访结果提示13例生存，1例失访，生存时间2～53个月，平均生存时间19．8个月，中位生存时间18个月。形态学方面，瘤细胞以中-大细胞为主，多形性明显的经典型11例，免疫母细胞型2例，小细胞型1例。所有病例多数肿瘤细胞（〉75％）表达CD30。结论PC—ALCL是一种预后很好的少见淋巴瘤类型，皮肤结节、中大细胞浸润、CD30弥漫阳性为其主要病理学特征，

Objective To summarize the morphological and immunohistological and clinical manifestatieal features of primary cutaneous anaplastic large cell lymphoma （PC-ALCL）. Methods We analyzed retrospectively the morphological and immunohistological and clinical data of 14 cases with PC-ALCL and summarized their features. Results Fourteen cases of PC-ALCL were studied. Thirteen cases were followedup in which all eases were alive. There were 11 cases in common type which showed medium to large-sized cells with predominant pleomorphism, 2 cases in immunoblastic type and 1 case in small cell type. hnmunohistochemical staining showed that more than 75 % tumor cells expressed CD30 in every case. Conclusion PC-ALCL is an uncommon subtype of lymphoma with an good prognosis. It is characterized by cutaneous nodules, the inflitartion of medium to large-sized cells and the diffuse expression of CD30.