锌指蛋白A20与树突状细胞

Zinc finger protein A20 and dendritic cell

锌指蛋白A20（A20）是一种具有泛素化修饰作用的锌指蛋白，在肿瘤坏死因子（TNF）、白细胞介素-1（IL-1）和脂多糖（LPS）等诱导刺激下高度表达，并能通过限制NF—κB活性的方式调节树突状细胞（DC）的成熟、细胞因子的产生及免疫活性。对A20的生物学特征、参与机体免疫反应的途径及其对DC细胞的成熟和功能的影响进行综述。

As a zinc finger protein with ubiquitin-modifying activity, A20 is highly expressed in most mammalian cell in response to stimuli of tumor necrosis factor （TNF）, Interleukin-1（IL-1）, lipopolysaccharide （LPS） and other factors. A20 has been found to play a crucial effect in control of the cell maturation, cytokine production and immunostimulatory potency of dendritic cells （DCs） via modulating down-regulation of NF-κB signaling transduction pathway. In this brief review, we descript the biological characteristics of A20 and the involvement of the A20 in the pathway of the immune responses toward to the DC cell maturation and immunostimulatory potency.