急性胰腺炎134例临床抗菌药物应用分析

An analysis of the use of antibiotics in the treatment of acute pancreatitis

目的:通过调查134例急性胰腺炎住院患者抗菌药物的使用情况,了解抗菌药物使用的合理性。方法:采用限定日剂量(DDD)、药物利用指数(DUI)及住院天数等指标,分析134例急性胰腺炎住院患者抗菌药物的使用情况;并以中国急性胰腺炎的诊疗指南为标准,初步调查抗菌药物的应用是否有用药指征。结果:有86.57%的病例基本符合应用抗菌药物的指征。大多数患者抗菌药物的DUI≤1.0。DDDs排序结果:硝咪唑类(35.90%)和头孢菌素类(29.37%)、头孢哌酮/酶抑制剂(15.09%)达全部DDDs的80.36%。二联用药以头孢哌酮/他唑巴坦与奥硝唑联用最多(14.89%)。结论:在急性胰腺炎抗菌药物的使用方面,我院用药情况大部分是合理的,但还有少部分病例在抗菌药物的剂量、疗程、联用药物及应用指征的把握方面需进一步提高。

OBJECTIVE To improve the rational use of antibacterials by an analysis of the application of the drugs in the treatment of patients with acute pancreatitis. METHODS The use of antihacterials in the treatment of 134 cases of patients with acute pancreatitis was analyzed with indexesincluding defined daily dose （DDD） ,drug utilization index（DUI） and hospital- ized days. RESULTS 116 cases （86. 57%） met the criterion of employing antibiotics. The DUI of antibacterials in the majority of patients were equal to or less than 1.0. The classified sequence of DDDs showed that the sum of antianaerobic-microbacterial （35.90%）, cephalosporins （29. 37 %） and cefoperazone/tazobatam （ 15.09% ） accounted for 80. 36% of the total DDDs . The usage of ornidazole plus cefoperazone / tazobatam （14. 89%） ranked the first among the combined application of antibiotics. CONCLUSION Nonclusion The antibiotic regimen in the majority of cases were of administration, The issues posed by some cases warranted us to improve the regimen of antibiotics over the fields including justification of the criterion, combined application of antibacterials,dosage and length of the treatment.