前列腺癌双睾切除患者与代谢综合征关系研究

Association between bilateral orchidectomy and metabolic syndrome in males with prostate cancer

目的评估前列腺癌患者双睾切除术后代谢综合征患病风险。方法研究对象为100例老年男性,以美国国家胆固醇教育计划成人治疗小组第三次报告(NCEP-ATP Ⅲ)提出的诊断代谢综合征的标准。实验组为50例因前列腺癌行双睾切除术后1年以上的患者,对照组为上海市男性健康俱乐部50名年龄匹配的男性,测身高、体重、腰围、血压、空腹血糖、血脂、血清总睾酮,计算体重指数(BMI)。分析患者行双睾切除术后代谢综合征的风险是否增加。结果患者双睾切除后体重指数、腰围、甘油三脂、空腹血糖明显高于对照组(P<0.01),而血清总睾酮、高密度脂蛋白明显低于对照组(P<0.01),血压、总胆固醇、低密度脂蛋白与对照组比较差异无统计学意义(P>0.05)。结论前列腺癌患者双睾切除后1年以上,代谢综合征的风险明显增加,预示这些患者有更高的心血管疾病风险。

Objective To evaluate the prevalence of metabolic syndrome in men with prostate cancer after bilateral orchidectomy. Methods Total of 100 aged participants were enrolled in this study. Diagnosis criteria of MS was defined by modified the National Cholesterol Education Program-Adult Treatment Panel Ⅲ（NCEP-ATP Ⅲ）. Experimental group was fifty men who received bilateral orchidectomy because of prostate cancer, control group was fifty age-matched men of Shanghai Men＇s Health Club. Height, weight, waist circumference, blood pressure, fasting blood glucose,fasting lipid, total serum testosterone and body mass index（BMI） were measured in all participants. We then analyzed if men who received bilateral orchidectomy because of prostate cancer had more hazard to control. Results Mean age was similar between the two groups. Men who received bilateral orchidectomy because of prostate cancer had high score in body mass index（BMI）, waist circumference, triglyceride（TG） and fasting blood glucose in contrast with that of control group （P〈0.01）, but their total serum testosterone and high density lipoprotein（HDL） were significantly lower than that. of control group （P〈0.01）. There were no significant differences in blood pressure, cholesterol, low density lipoprotein （LDL） between two groups （P〉0.05）. Conclusion One year later, patients who underwent bilateral orchidectomy had more hazard to have metabolic syndrome, which indicates that they will have higher cardiovascular risk. Prospective studies on this association merit to be further investigated.