舍曲林对抑郁症患者细胞因子平衡的影响

Effect of Sertraline on Cytokine Balance in Patients with Depression

目的:探讨舍曲林对抑郁症患者细胞因子平衡的影响。方法:酶联免疫吸附法检测26例抑郁症患者(抑郁组)舍曲林治疗前、后和28名正常人(对照组)的血清白细胞介素-2(IL-2)、白细胞介素-12(IL-12)、肿瘤坏死因子-α(TNF-α)、白介素-4(IL-4)和转化生长因子-β(1TGF-β1)水平。结果:抑郁组治疗前、后的IL-2、IL-12、TNF-α水平均明显高于对照组(P<0.01),IL-4、TGF-β1则较对照组降低(P<0.01);治疗后抑郁组IL-2、IL-12、TNF-α水平较治疗前降低(P<0.01),而IL-4、TGF-β1较治疗前升高(P<0.01)。结论:抑郁症患者存在细胞因子失衡和广泛的免疫激活。舍曲林可能通过对免疫系统调节产生抗抑郁作用。

OBJECTIVE：To investigate the effect of sertraline on cytokine balance in patients with depression. METHODS： Serum levels of interleukin2（IL-2）, interleukin12（IL-12）, interleukin4（IL-4）, tumor necrosis factor-alpha （TNF-α） and transforming growth factor beta （TGF-β1） were measured in 26 patients with depression（depression group） before and after treatment and 28 healthy volunteers （control group） by enzyme linked immunosorbent assay （ELISA）. RESULTS： As compared with control group, in depression group the serum levels of IL-2, IL-12, TNF-α were significantly higher than in control group; the serum levels of IL-4, TGF-β1 were significantly lower than in control group（P0.01）. After treatment, the serum levels of IL-2,IL-12,TNF-α in depression group were significantly decreased but serum levels of IL-4, TGF-β1 were increased than those before treatment （P0.01）. CONCLUSION： Patients with depression show cytokine unbalance and general immune activation. Anti-depressant activity of sertraline might be performed by adjusting immune system.