延胡索细粉与超微粉溶出度比较

Comparison of Dissolution of Corydalis yanhusuo Fine Powder and Its Ultrafine Powder

目的:考察并比较延胡索细粉和超微粉的溶出度,为改进、提高药品的生物利用度提供依据。方法:以桨法制备供试品溶液,高效液相色谱法测定延胡索乙素的含量,计算延胡索细粉和超微粉的溶出率。结果:延胡索超微粉的溶出度和溶出率均大于细粉。结论:微粉化有利于药物有效成分的溶出。

OBJECTIVE：To investigate the dissolution of Corydalis yanhusuo fine powder and its ultrafine powder in order to provide theory basis for improving the bioavailability of preparation.METHODS：The paddle method was applied to prepare test sample solution and HPLC was used to determine the content of tetrahydropalmatine.The dissolution of C.yanhusuo fine powder and its ultrafine powder were calculated.RESULTS：The dissolution and dissolution rate of C.yanhusuo ultrafine powder were all higher than its fine powder.CONCLUSION：Micronization contributes to the dissolution of effective components.