姜黄素类似物的微波合成及抗肿瘤活性研究

Microwave synthesis and antitumor activity of curcumin analogs

目的:设计合成4个姜黄素类似物并研究其体外抗肿瘤活性。方法:分别用芳醛和环己酮为原料在盐酸的催化作用下,微波合成目标化合物;采用台盼蓝细胞计数法对目标化合物的抗肿瘤活性进行研究。结果:4种具有二烯单酮结构的姜黄素类似物可明显地抑制K562细胞的活性。结论:姜黄素类似物具有较好的抗肿瘤活性。

Objective：To synthesize four curcumin analogs and evaluate their antitumor activities.Methods：Four curcumin analogs were synthesized by coupling the appropriate aromatic aldehyde and cyclohexanon with HCl catalysis under microwave irradiations.The antitumor activities of these analogs were evaluated by trypan blue staining assay.Results：Four curcumin analogs with structural unit of diene-ketone were synthesized and their structures were determined.They showed inhibitory effects in K562 cells in vitro.Conclusion：Four curcumin analogs are synthesized and have antitumor activities.