多发伤全身性炎症反应综合征与多器官功能不全关系的研究

Study on the correlation of systemic inflammatory response syndrome with multiple organ dysfunction of multiple trauma patient

目的：研究多发伤患者发生SIRS和MODS的情况以及两者之间的关系，从而为防治MODS，降低多发伤患者死亡率提供理论依据。方法：选择1994年10月至1997年10月3年间急救医学中心收治的60例多发伤者的临床资料，按照1991年8月ACCP和SCCM会议的诊断标准，比较SIRS和MODS的发病率。结果：60例多发伤患者中，发生SIRS者52例，发病率为86．67％，发生MODS者6例，发病率为10％，均发生了SIRS，死亡4例，死亡率为6.67％，1例为入院即刻死亡，3例均发生了SIRS。结论：大多数多发伤患者发生了SIRS，SIRS至MODS是一个连续的发展过程，MODS有很高的死亡率，多发伤患者发生SIRS后导致MODS以及死亡率，与以往文献报道相比，有明显下降。

Objective: The study was designed to explore the correlation of systemic inflammatory response syndrome (SIRS) with multiple organ dysfunction syndrime (MODS) and to propose a theoretie basisfor reducing the mortalily of patients with multiple traumas Methods: Sixty Patients with multople traumas in ourcenter freated from Oct. 1994 to Oct. 1997 were selected. Compared with the morbidity of SIRS and MODS,according to the diagnosic standards of ACCP and SCCM 1991. Results: of 60patients, 52 of them sufferedfrom SIRS and 6 of them from MODS. The morbidity is 86.67percent and 10percent respectively. Four of themdied. One died immediately after admitted to the emergency ward and the other three patients all suffered fromSIRS. Concluusion: Most of patients with multiple traumas suffered from SIRS, the process from SIRS toMODS is successive. Compared with that from the literature, the morbidity and mortality of our patients arelower.