复方甲地孕酮治疗药物流产后异常出血的观察

Observation of compound megestrol acetate in treatment of abnormal bleeding after medical abortion

目的:寻找一种简单、有效、副作用小的治疗方法,减少药物流产后阴道出血量,缩短出血时间,降低清宫率。方法:观察组:确诊后于当天开始,晚饭后0.5h服用复方甲地孕酮片,每日1片,连服22天停药;对照组:确诊后于当天开始使用益母草颗粒20gbid促进宫子收缩,口服环丙沙星0.2gbid、甲硝唑片0.6gbid预防感染,连用5天。两组均于用药第6天复诊或电话随访,以便观察止血情况,仍未止血则根据情况加用其他药物或行清宫术。结果:观察组有90例(97.8%)患者均在服药4天内血止;观察组2天内阴道出血停止者明显多于对照组(P<0.05);观察组治疗5天后仍有阴道流血例数明显少于对照组(P<0.01)。结论:复方甲地孕酮片治疗药物流产后子宫异常出血,止血迅速,副作用小,可避免刮宫处理。

Objectives：To find a simple,efficient,and less side effects of treatment methods,in order to reduce the vaginal bleeding volume after medical abortion,and shorten the bleeding time and reduce the rate of curettage. Methods：Observer group：daily use of compound megestrol acetate one tablet to observation group,long-term usage 22 days; Control group：using motherwort granule 20g bid to promote the uterus to contract,oral ciprofloxacin 0.2g bid and metronidazole 0.6g bid to prevent infection,together for 5 days. Two groups on the 6th day of subsequent visit or the telephone revisit,with the aim of observing the hematischesis situation,If the bleeding does not stop,plus other drugs or curettage surgery. Results：The observation group has 90 patients （97.8%） to stop the bleeding in 4d; the patients of the observion group stop bleeding in two days significantly more than the control group （P〈0.05）; 5 days after treatment the patient is still bleeding,observation group was significantly less than the control group（P〈0.01）. Conclusion：Compound megestrol acetate tablets therapy abnormal uterine bleeding after medical abortion,with the characteristics of rapid hemostasis,less side effects and can be avoided dealing with curettage.