急性胰腺炎患者血清髓系细胞触发受体-1水平及其临床应用价值

Serum levels of triggering receptor expressed on myeloid cells-1 and inflammatory factors in patients with acute pancreatitis and its clinical values

目的 分析急性胰腺炎患者早期血清髓系细胞触发受体-1（TREM-1）水平及其与炎症因子的关系,探讨其预测急性胰腺炎预后的价值.方法 ELISA法检测19例早期急性胰腺炎患者血清TNF-α、IL-8、IL-1β及TREM-1水平,分析它们之间的关系,并与20例正常人比较.结果 急性胰腺炎组TNF-α、IL-8、IL-1β及TREM-1水平分别为（52.26±12.98）pg/ml、（20.18±9.81）pg/ml、（35.57±13.34）pg/ml和（83.09±32.49）pg/ml,对照组分别为（18.69±6.42）pg/ml、（9.81±4.80）pg/ml、（14.94±5.16）pg/ml和（8.44±8.42）pg/ml,两组比较有显著差异（P值均〈0.01）.急性胰腺炎患者TREM-1与各项炎症因子均呈正相关（P值均〈0.05）.TREM-1对于急性胰腺炎患者预后判断的敏感性为77.8%,特异性为70.0%,优于TNF-α、IL-8、IL-1β.结论 TREM-1可以影响急性胰腺炎患者血清炎症因子水平,对急性胰腺炎预后判断有一定价值.

Objective To determine the serum levels of triggering receptor expressed on myeloid cells-1 （TREM-1）, analyse its relationship with inflammatory factors, and explore its clinical values. Methods Serum concentrations of TREM-1, TNF-α, IL-8 and IL-1β in 19 patients with early acute pancreatitis （AP） were measured by enzyme-linked immunoadsorbent assay and the relationship among them was analyzed, and it was compared with those of 20 normal controls. Results In patients with early AP, serum levels of TNF-α, IL-8, IL-1β and TREM-1 were （52.26±12.98） pg/ml, （20.18±9.81） pg/ml, （35.57 ± 13.34） pg/ml and （83.09 ± 32.49） pg/ml;while they were （18.69 ± 6.42） pg/ml, （9.81 ± 4.80） pg/ml, （14.94 ± 5.16） pg/ml and （8.44±8.42） pg/ml in control group, and there was significant difference between the two groups （P 〈 0.01）. TREM-1 was positively correlated with other inflammatory factors in patients with early AP, and it had a sensitivity of 77.8%, specificity of 70.0% for prognosis prediction, which was better than TNF-α, IL-8, IL-1β. Conclusions TREM-1 may influence the leveLs of inflammatory factors and to some extent predict the early prognosis of AP.