首发抑郁症患者血清IL-18水平的研究

Levels of serum IL-18 in first-episode depressive patients

目的研究首发抑郁症患者血清白细胞介素18(IL-18)水平,探讨其与首发抑郁症病情严重程度及认知功能的关系。方法使用威斯康星卡片分类测验(WCST)、汉密尔顿抑郁量表(HAMD)对50例符合美国精神障碍诊断与统计手册第四版(DSM-Ⅳ)抑郁症患者进行评定,以50例正常人做对照,应用酶联免疫吸附技术(ELISA法)检测血清IL-18水平。结果患者组血清IL-18水平明显高于对照组(P<0.001);WCST中的总错误数、持续错误数、非持续错误数均高于正常对照组,总正确数、正确分类数低于对照组(P<0.001);血清IL-18水平与HAMD量表中的总分、阻滞、绝望因子分及WCST中的总错误数和持续性错误数呈正相关;与WCST中的总正确数呈负相关。结论首发抑郁症患者组与对照组之间血清IL-18水平有显著性差异,且血清IL-18水平越高其认知功能损害程度越重。

Objective To study the serum Interleukin-18（IL-18） of the first-episode depressive patients and the relationship between serum IL-18 and the severity,cognitive functions of first-episode depression.Method Fifty first-episode depressive patients and fifty normal control objects were enrolled.Depression was diagnosed using diagnostic and statistical manual of mental disorders-Ⅳ（DSM-Ⅳ）.Objects were screened by hamilton depression scale（HAMD）.The cognitive functions of objects were evaluated by wisconsin card sorting test（WCST）.The levels of serum IL-18 were detected by enzyme-linked immunosorbent assay（ELISA）.Results The levels of serum IL-18 in first-episode depression group were significantly higher than those in normal control（P〈0.01）.The higher scores of total error numbers,preservative errors,random errors of WCST and lower score of total corrects and categories completed were found in first-episode depression group（P〈0.01）.There were positive correlations between serum IL-18 and total scores of HAMD,retardation and desperation,total error number,preservative errors in WCST,respectively,and negative correlation with total corrects in WCST.Conclusion IL-18 levels in serum are significantly higher in the first-episode depressive group than in control group.The heavier cognitive dysfunction,the higher IL-18 levels in serum in the first-episode depressive group.