摘要
目的 探讨体重指数（BMI）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、脂蛋白a（Lp（a））、尿酸（UA）与冠状动脉血管病变程度的关系.方法 随机选取住院患者（疑诊冠心病）184例,所选患者无吸烟、饮酒史,无高血压病、糖尿病史,住院期间进行BMI,LDL-C,HDL-C,Lp（a）,UA的测定,其中LDL-C,HDL-C,Lp（a）,UA通过自动生化分析仪测出,BMI通过测量身高、体重计算出,所选患者住院期间进行了选择性冠脉造影（selective celiac angiography,SCAG）术,根据SCAG术的检查结果进行Gensini评分,并根据评分结果将其分为3组：对照组、轻度病变组、重度病变组,利用方差分析及多元线性回归进行分析.结果 BMI,LDL-C,Lp（a）,UA与冠脉血管病变程度呈正相关（P＜0.05）,HDL-C与冠脉血管的病变程度呈负相关,其中LDL-C,Lp（a）,UA对冠脉血管病变程度的影响较大.结论 LDL-C,Lp（a）,UA与冠状动脉病变的严重性呈显著相关.
Objective To explore the relationship between the change of BMI,LDL-C,HDL-C,Lp（a）,UA and the severity of coronary artery disease. Methods One hundred and eighty four patients （ suspected coronary heart disease） with no smoking,no drinking, no hypertension and no diabetes in hospital were randomly selected. All patients underwent selective celiac angiography （ SCAG）. They were divided into control group, mild lesions group and severe lesions group according to Gensini score. LDL-C, HDL-C, Lp （ a） , UA were detected with automatic biochemical analyzer. The height and weight were measured to calculate the BMI. Analysis of variance and multiple linear regression analysis were carried out. Results BMI, LDL-C,Lp（ a） , UA levels correlated positively with the severity of coronary artery disease（P 〈 0.05 ） , but HDL-C negatively with it. LDL-C, Lp （a） and UA played a key role in coronary artery disease. Conclusion LDL-C,Lp（a） ,UA significantly correlated with the severity of coronary artery disease.
出处
《潍坊医学院学报》
2010年第1期32-34,共3页
Acta Academiae Medicinae Weifang
