摘要
目的探讨他克莫司软膏联合窄谱中波紫外线(NB-UVB)治疗白癜风的疗效和安全性。方法82例白癜风患者随机分成两组。治疗组43例,外用他克莫司软膏,2次/d,NB-UVB光疗,每周2次,疗程16周。对照组39例单纯予NB-UVB光疗,用法同上。结果治疗组有效率为72.1%,对照组为48.7%,两组有效率差异有显著性(P<0.05)。治疗组皮损位于面颈部、躯干和四肢者疗效优于对照组(P<0.05),两组肢端皮损疗效差异无显著性(P>0.05)。患者均未出现严重不良反应。结论他克莫司软膏联合NB-UVB治疗位于面颈部、躯干和四肢的白癜风疗效好,不良反应少。
Objective To investigate the efficacy and safety of tacrolimus ointment combined with narrow-band ultraviolet B (NB-UVB) phototherapy in the treatment of vitiligo. Methods Eighty-two patients with vitiligo were divided into two groups randomly. Forty-three patients of treatment group were treated twice daily with tacrolimus ointment combined with NB-UVB phototherapy twice weekly for 16 weeks. Similarly, thirty-nine patients of control group were only treated with NB-UVB phototherapy twice weekly for 16 weeks. Results The total effective rate of treatment group was 72.10% and that of control group was 48.70%. There was significant difference between two groups(P 〈0.05 ). The effect of treatment group is superior to that of control group to the vitiligous lesions located on face neck trunk and extremities(P 〈0.05 ). However, there was not statistical significance between two groups in the effective rate of acral lesions(P 〉0.05). No serious adverse events were recorded in both groups. Conclusion The combination of tacrolimus ointment with NB-UVB phototherapy can represent an effective and well-tolerated approach to vitiligo located on face neck trunk and extremities.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2010年第5期440-441,共2页
The Chinese Journal of Dermatovenereology