咪喹莫特联合激光预防女性尖锐湿疣复发机制探讨

The Exploration about the Mechanism to the Recurrence of Condyloma Acuminatum Treated with Imiquimod and Laser

目的分析咪喹莫特联合激光治疗尖锐湿疣的疗效及复发情况与局部LC数量变化的关系,探讨复发产生的部分机制。方法联合使用咪喹莫特和激光治疗尖锐湿疣。根据疗效分为治疗有效组和治疗后复发组各30例。收集治疗前病理标本,用免疫组化法标记CD1a,分析局部LC数量变化。结果30例治疗有效标本LCCD1a+数目为13.23±5.12个,咪喹莫特治疗后复发组的LCCD1a+数目为4.77±2.81个,与治疗有效组差异有显著性(P<0.05)。结论咪喹莫特治疗后复发病人局部皮肤中的朗格汉斯细胞数量较治疗有效者少。可能与其复发机制有关。

Objective To study the curative effect, recurrence rate and the changes of quantity of langertlans cells of combination of imiquimod and laser on condyloma acuminatum, and approach to the mechanisms of condyloma acuminatum＇s drug resisitance to imiquimod. Method Combination of imiquimod and laser in treatment of condyloma acuminatum. According to the curative effect, the patients were divided into two groups ： efficacy group and ineffective group. Each group have 30 patients, the pathology specimens were obtained before therapy and were marked by CDla with immunohistochemistry to study the the changes of quantity of langerhans cells. Results The number of CD1a ^＋ cells in the efficacy group were 13. 23 ± 5.12. And those in inefficacy group were 4.77 ±2.81, which were weaker than those of the efficacy group statistically （ P 〈 0.05 ）. Conclusions The skin langerhans cells of the patients with drug resisitance to imiquimod were less than the patient who were sensitive to imiquimod. It is maybe related to the mechanism of condyloma acuminatum＇s resisitance to imiquimod.