82例莪术油注射液不良反应文献分析

Literature Analysis of 82 Adverse Drug Reaction Reports of Zedoray turmeric oil Injection

目的探讨莪术油注射液致不良反应的一般规律及特点,为临床合理用药提供参考。方法对国内医药期刊报道的82例莪术油注射液不良反应病例进行分类统计分析。结果莪术油注射液所致不良反应与性别无关,多发生于≤10岁年龄组,其不良反应发生时间多为用药后的10分钟内。不良反应累及机体多个系统-器官,临床表现复杂多样,主要表现为变态反应,严重者可出现过敏性休克。结论临床医师、药师应了解莪术油注射液所致不良反应的规律和特点,加强其用药监测,以减少不良反应的发生。

Objective To explore the general pattern and characteristics of adverse drug reactions（ADR） induced by Zedoray turmeric oil injection so as to provide references for clinical rational drug use.Methods A statistical analysis was conducted on 82 Zedoray turmeric oil injection-induced ADR cases reported in domestic medical journals.Results ADR of Zedoray turmeric oil were independent of patient＇s sex,and mostly occurred in the ≤10 ages group.They usually occurred in the first 10 minutes after taking the drug.ADR could involve in multiple organs and systems,and clinical manifestations were various,mainly were allergic reaction.Severe allergic reaction could result in anaphylactic shock.Conclusion Doctors and pharmacists should know the pattern and characteristics of ADR,and the use of Zedoray turmeric oil injection should be under strict monitoring to reduce the occurrence of serious ADR.