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DNA甲基化与基因表达调节 被引量：7

DNA Methylation and Gene Express Regulation
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摘要 DNA异常甲基化是一种表观遗传改变,常发生在启动子区的CpG岛。某些基因甲基化与基因表达密切相关,在生命过程中扮演着重要功能。一方面,DNA甲基化与高等动物的生长发育密切相关,另一方面,DNA甲基化和其他生命过程也有重要的联系。如X染色体失活、基因组印记、发育调控及细胞分化和肿瘤发生发展中起重要作用。 Aberrant DNA methylation is an epigenetic modification,which often occurred CpG-island of promoter. Some gene methylation has been lincked to gene express which plays an important role in the life process. On the one hand,DNA methylation related high animals development and other life process,such as X-chromosome inactivation, genome impress,regulatoin of develop process play an important role.
作者 陈秀莉 马利兵
机构地区 内蒙古科技大学数理与生物工程学院 包头师范学院生物科学与技术学院
出处 《生物技术通报》 CAS CSCD 北大核心 2010年第5期7-10,共4页 Biotechnology Bulletin
基金 内蒙古自治区高等学校科学技术研究项目(NJ09093)
关键词 DNA甲基化 CPG岛 基因表达调控 DNA methylation CpG-island Gene express regulation
分类号 Q75 [生物学—分子生物学]
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参考文献15

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二级参考文献12

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生物技术通报
2010年 第5期

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