平肝散降解肝内纤维定量变化及意义

Effect of the Anti hepatic Fibrosis by Pinggansan Granule in Mice Infected with Schistosoma Japonicum

采用日本血吸虫感染动物制备小白鼠病理性肝纤维化模型。并观察平肝散对早期血吸虫性肝纤维化病理过程的阻断及逆转作用。中药组动物血清Ⅰ型前胶原（ＰＣ－Ⅰ）及血清Ⅲ型前胶原（ＰＣ－Ⅲ）含量减少，血清Ⅲ型前胶原与对照组比较有显著性差异；动物血清中肿瘤坏死因子（ＴＮＦ－α）及白细胞介素６（ＩＬ－６）均低于实验对照组；肝组织中羟脯氨酸（ＨＹｐ）含量下降。图象分析结果表明平肝散能使日本血吸虫性肝虫卵肉芽肿的周长、最大直径及最小直径缩小，肝内病灶中网状纤维减少，增生纤维组织所占面积下降，肝病灶炎性细胞浸润明显减轻。

Morphometric techniques,RIA and histochemical techniques were applied to study effect of the anti hepatic fibrosis by Pinggansan Granule.The results showed that the percentage of the area full of reticular fiber in affected location was smaller than that of control group,the perimeter,long and short diameter of the egg granuloma in the experimental mice was decreased.And PC Ⅲ,PC Ⅰ and HY p in the drug treated group was decreased.