动态血压正常高限者的左室肥厚

Left Ventricular Hypertrophy in Patients with Normal high Ambulatory Blood Pressure

目的：观察动态血压为正常高限者的左室肥厚情况，为该患者群靶器官损害的防治策略提供依据。方法：根据２４小时动态血压监测结果将病人分为３组：Ｎ组（正常血压组）、ＮＨ组（血压正常高限组）和Ｈ组（高血压组）。以超声心动图检测左室舒张末期内径，舒张末期室间隔和左室后壁厚度等，计算左室重量指数（ＬＶＭＩ）。结果：Ｈ组（１２９±４１）和ＮＨ组（１１５±３２）的ＬＶＭＩ明显高于Ｎ组（９７±２３，Ｐ＝０．００００１和０．００５），Ｈ组和ＮＨ组间无统计学差异。结论：动态血压正常高限者左室肥厚程度明显重于血压完全正常者。

Objective:Left ventricular hypertrophy in patients with high but in normal range blood pressure during ambulatory blood pressure(ABP) monitoring was determined in order to find evidence for the prophylaxis and management of the target organ damage in these patients.Method:The patients were divided into 3 groups according to the results of ABP monitoring:group N(normotensive group),group NH(normal high ABP group) and group H(hypertentsion group).The left ventricular diameter at end diastole and the thickness of interventricular septum and posterior wall were measured with echocardiography.Left ventricular mass index (LVMI) was calculated.Results:LVMI in group H(129±41) and group NH(115±32) were markedly higher than that in group N(97±23, P =0 00001 and 0 005).There was no significant difference with LVMI between group H and group NH.Conclusion:Left ventricular hypertrophy in patients with normal high ABP was much more severe than that in normotensives.Prevention and treatment measures to target organ damage should be taken actively in these patients.