应用肺静脉血流图结合二尖瓣血流图评价糖尿病左心室舒张功能

Applying Pulmonary Vein Flow Graph Combined with Mitral Valve Flow Graph by Echo Doppler to Evaluate Left Ventricular Diastolic Function in Diabetic Patients

目的：应用肺静脉血流图结合二尖瓣血流图评价糖尿病心脏病变引起的左室舒张功能变化，旨在探讨更敏感的检测方法。方法：非胰岛素依赖型糖尿病（ＮＩＤＤＭ）３３例，对照组选择３３例健康者；使用ＨＰＳＯＮＯＳ２５００超声仪，呼气末记录二尖瓣血流图和肺静脉血流图；采用ＳＰＳＳ软件包进行统计学处理，观察指标间运用ｔ检验。结果：二尖瓣血流图仅能显示左室舒张早期功能减退；肺静脉血流图ＮＩＤＤＭ组以大Ｓ加小Ｄ波型为主，与对照组相比Ｖｓ／Ｖｄ比值增大（Ｐ＜０．０１），Ｄ波减小（Ｐ＜０．０１）；ＡＲＶ（ｃｍ／ｓ）为３８．２０±８．０６与对照组（３１．３５±５．００）相比增大（Ｐ＜０．０１）。结论：糖尿病性心肌病变不仅导致左室舒张早期功能减退，同时导致左室舒张晚期顺应性的下降；

Objective:To seek for a new Echo Doppler method which can more sensitively detect changes of left ventricular diastolic function in NIDDM.Method:33 patients with diabetic mellitusⅡ and 33 controls were investigated.Pulmonary vein flow graph and mitral value flow graph were calculated in both groups.Results:Mitral value flow graph showed that only a functional decrease in the early diastolic stage of left ventricular was found while pulmonary vein flow graph showed that a large S and a small D waves and a increased ratio of Vs/Vd were found in NIDDM group which are significantly different from control group( P <0 01).ARV(cm/s) in NIDDM group was significantly increased compared with controls(38 20±8 06 versus 31 35±5 00, P <0 01).Conclusion:The results suggested that not only a functional decrease in the early diastolic stage of left ventricular but also a compliance decrease in the late diastolic stage of the left ventricular in patients with NIDDM.