肝炎病毒在朝鲜族原发性肝癌发生中相互作用的分析

An Analysis of the Interaction of Hepatitis Virus in Primary Hepatocellular Carcinoma in Korean of Yanbian

采用酶联免疫吸附法（ＥＬＩＳＡ）对１１２例延边地区朝鲜族原发性肝癌（ＰＨＣ）患者血清进行了乙型、丙型和丁型肝炎病毒（ＨＢＶ、ＨＣＶ和ＨＤＶ）的检测。结果，ＰＨＣ组ＨＢＶ、ＨＣＶ感染率显著高于对照组，ＯＲ值分别为２２．３３和６．２０；合并ＨＢＶ、ＨＣＶ混合感染的ＯＲ值为８５．８７，其相对超额危险度为３６．３１。其中６１例ＨＢｓＡｇ阳性肝癌的ＨＤＶ血清标志检出率２６．２２％，明显高于６５例ＨＢｓＡｇ阳性的肝炎对照组。提示ＨＢＶ、ＨＣＶ感染在朝鲜族ＰＨＣ的发生中有显著的病因协同作用；且ＨＢＶ。

The serum marks of HBV,HCV,and HDV in 112 korean patients with PHC in Yanbian area were examined by ELISA.The results showed that the prevalence of HBV and HCV in patients were significantly higher than that in controls,the va lues of OR were 22 33 and 6 20 respectively,the value of OR in both HBV and HCV infection was 85 87,the relative excess risk was 36 31.The positive rate for HDV marker in 61 HBsAg positive PHC was significantly higher than that in hepatitis patients with positive HBsAg.Both HBV and HCV infection had obviously cooperating functions of causing PHC.Mixed infection of HBV and HDV was important to exacerbate liver disease.