乳腺良恶性病变组织c-met蛋白和转化生长因子α的表达及意义

THE EXPRESSIONS AND SIGNIFICANCE OF C MET ONCOPROTEIN, TRANSFORMING GROWTH FACTOR α IN BENIGN AND MALIGNANT LESIONS OF BREAST

应用免疫组化法测定５０例乳腺癌和１２例乳腺良性病变组织中ｃｍｅｔ蛋白及转化生长因子α（ＴＧＦα）的表达。结果：乳腺癌组织中ｃｍｅｔ蛋白及ＴＧＦα表达阳性率分别为２６．０％和４２．０％，乳腺良性病变组织中两者表达阳性率分别为８．３％和２５．０％；组织学分级为Ⅰ级，雌激素受体（ＥＲ）、孕激素受体（ＰＲ）及癌胚抗原（ＣＥＡ）为阴性的病例中，ｃｍｅｔ蛋白及ＴＧＦα表达阳性率明显低于组织学分级Ⅲ级，ＥＲ、ＰＲ及ＣＥＡ为阳性者（ｃｍｅｔ及ＰＲＰ＜０．０１；ＴＧＦα、ＰＲ和ＣＥＡＰ＜０．０５；余Ｐ＞０．０５）。

The expressions and significance of c met oncoprotein and transforming growth factor α (TGF α) were studied by immunohistochemical method in 50 cases of breast cancer (BC) and 12 cases of benign lesions of breast (BL). The positive rate of c met, TGF α in BC was 26.0% and 25.0% respectively, in BL was 8.3% and 25.0% respectively. The positive rate of c met oncoprotein was lower in the cases of histologic Grade Ⅰ, positive of ER and PR or CEA than that of histologic Grade Ⅲ, negative of ER and PR or CEA. The positive rate of TGF α was lower in the cases of histologic Grade Ⅰ, negative of ER and PR or CEA than that of histologic Grade Ⅲ, positive of ER and PR or CEA. These results suggest the expression of c met and TGF α might be related to the carcinogenesis and development or endocrine state of BC.