血清凝集肿瘤细胞活性与肿瘤转移的相关性及其临床意义

Evaluation of the relationship between human sera′s tumor cell agglutinating activity and tumor metastasis in diagnosis of malignant tumor

目的：探讨血清凝集肿瘤细胞活性与肿瘤转移的相关性及其对恶性肿瘤临床诊断的意义。方法：采用体外细胞凝集实验，通过计算肿瘤细胞凝集率测定血清活性。结果：正常人、良性肿瘤患者、早期及中晚期恶性实体瘤患者的血清均诱导人鼻咽癌细胞凝集，凝集率分别为３５２％±９５％、３８１％±１１２％、５０７％±１１６％及７２３％±１０４％；血清此活性在恶性肿瘤诊断上的灵敏度为９０６％，特异性为９２１％，准确性为９１３％。结论：血清凝集肿瘤细胞活性与肿瘤转移呈正相关，其可能是一新的广谱恶性肿瘤标志，在恶性肿瘤的临床诊断及预后上具有重要应用价值。

Objective: The study was to evaluate the relationship between tumor cell agglutinating activity of human sera and tumor metastasisin diagnosis of malignant tumor.Methods: Human sera′s tumor cell agglutinating activity was assayed by semi-quantification of the aggregation of human nasopharyngeal carcinoma cell(CNE-2L 2) in vitro.Results: CNE-2L 2 cell aggregation was induced and enhanced by the sera of normal persons,benign,early and advannced malignant tumor patients,and the cell aggregation percentage was 35.2%±9.5%,38.1%±11.2%,50.7%±11.6% and 72.3%±10.4%,respectively.The diagnostic sensivity of malignant tumor was 90.6%,the specificty was 92.1%,and the accuracy was 91.3% Conclusion: The results suggests that tumor cell agglutinating activity of human sera was postively related with tumor metastasis and may be a potential marker of malignat tumor and a valuable index in diagnosis and prognosis of malignant tumor.