2型糖尿病微血管病变患者脂蛋白(α)的变化

The change of lipoprotein(α) in NIDDM with microangiopathy

目的：探讨２型糖尿病人血清脂蛋白（α）水平与发生微血管病变的关系。方法：测定９１例糖尿病人，包括４４例伴微血管病变和４７例未发生微血管病变者的血清脂蛋白（α）（Ｌｐ（α），ＡｐｏＡ，ＡｐｏＢ，ＴＣ，ＴＧ；血ＨｂＡｌ；尿ＮＡＧ和ＮＡＧＢ等指标，与３２例对照组进行比较。结果：微血管病变的糖尿病人血清Ｌｐ（α）显著高于对照组。糖尿病肾脏并发症患者Ｌｐ（α）水平与ＴＣ（ｒ＝０．２３，Ｐ＜００５），ＡＥＲ（ｒ＝０．６２，Ｐ＜０．０１），ＮＡＧＢ（ｒ＝０．５１，Ｐ＜００１）和ＮＡＧＩ（ｒ＝０．４１，Ｐ＜００５）呈现相关。结论：测定Ｌｐ（α）对辅助诊断糖尿病微血管病变有较好的临床价值。

Objective: Study the relation between Lp(α) and mcroangiopathy in NIDDM.Methods: The concentrations of Lp(α),ApA 1,ApoB,TC,TG,HbA 1,NAG were detected in 91 NIDDM,included 44 patients with microangiopathy.Results: The levels of Lp(α) in NIDDM with microangiopathy were higher than the controls significantly.The correlation was observed between Lp(α) and TC(r=0.23, P <0.05),AER((r=0.62, P <0.01),NAG B(r=0.51, P <0.01)and NAGI(r= 0.41, P <0.05).Conclusion: The measurement of Lp(α) is of good applicable value in auxiliary diagnosis for diabetic microangiopathy.