数值计算方法在生物电磁学中的应用

Application of numerical methods in biological electromagnetics

目的:介绍现有数值计算方法的特点,总结目前主流生物电磁仿真软件的不同侧重方向,并探讨生物电磁计算平台的发展趋势。资料来源:由作者检索万方数据库、Sciencedirect(Elsevier)数据库及IEEE数据库。资料检索时间为1999/2009。检索关键词包括"生物电磁,仿真,数值计算,FDTD"。共检索到83篇文献,其中中文28篇,英文55篇。手动检索资料包括软件的介绍和使用手册资料4份。资料选择:通过标题和摘要阅读进行初筛,选择最近发表的同种仿真方法的相关研究文献。结局评价指标:排除研究目的与课题无关的文献25篇,内容重复和陈旧的文献27篇,保留31篇中英文文献进一步分析。符合纳入标准的31篇文献中,综述、述评8篇,研究论文23篇。结果:常用的电磁场数值计算方法包括时域有限差分法、矩量法、有限元法。目前应用于电磁照射对生物体影响研究的仿真软件主要有SEMCAD-X,FEKO,XFDTD,HFSS及GEMS等多种。结论:未来生物电磁计算平台的发展趋势将融合多种数值计算方法,以增强对仿真对象的多种研究需要。此外,仿真界面人性化和建模流程便捷化也是未来改进的重点。

OBJECTIVE： To describe the characteristics of existing numerical methods, conclude current mainstream bio-electromagnetism simulation softwares, focusing on their different directions, and explore the developing trends of bio-electromagnetism computing platform. DATA SOURCES： A computer-based online search of Wanfang, Sciencedirect （Elsevier）, and IEEE database was performed for articles published between 1999 and 2009 with the key words ＂bio-electromagnetism, simulation, numerical simulation, FDTD＂ in Chinese and English. A total of 83 articles were collected, including 28 Chinese and 55 English. Four software introduction and user manuals were manually retrieved. DATA SELECTION： Articles were screened by reading the title and abstract, and the latest relevant research literatures in the same kinds of simulation methods were included. MAIN OUTCOME MEASURES： A total of 25 articles with no related content, and 27 repetitive and outdated studies were excluded. Finally, 31 Chinese and English articles were included for further analysis, involving 8 reviews and comments and 23 original articles. RESULTS： Common electromagnetic field numerical calculations include time domain finite difference method, moment method, and finite element method. Currently, the bio-electromagnetism simulation softwares used in electromagnetic radiation on organism include SEMCAD-X, FEKO, XFDTD, HFSS and GEMS. CONCLUSION： Future bio-electromagnetic computing platform is expected to integrate a variety of numerical methods to meet the research needs of a variety of simulation objects. In addition, interface facilitation of simulation and flowsheet of modeling will be the focus of future improvements.