不同浓度的硝普钠治疗慢性心力衰竭疗效观察

目的探讨不同浓度的硝普钠治疗慢性心力衰竭(chronic heart failure,CHF)的临床疗效。方法将我院2008年1月～2009年12月128例CHF患者随机分为四组,对照组、硝普钠低浓度、硝普钠中浓度、硝普钠高浓度四组,观察治疗前、后心功能改善情况。结果高浓度硝普钠治疗CHF疗效优于其它实验组(P<0.05),LVEF、LVDD、等观察指标都得到一定程度改善,治疗后CRP(10.75±1.02)、cTnT(0.01±0.01)及TNF-α(95.86±10.68)显著低于治疗前CRP(20.76±2.58)、cTnT(0.51±0.07)及TNF-α(149.65±16.78)水平(P<0.01)。结论高浓度硝普钠可以有效地治疗CHF。

Objective This study was carried out to evaluate the therapeutic effects of different concentration of sodium nitroprusside（SNP） on chronic heart failure（CHF）.Methods 128 patient with CHF were divided into four group at random,control group,low-SNP group,med-SNP group,high-SNP group,then observe the amelioration of heart function.Results There were signifi cantly differences in therapeutic effect between highSNP group and other groups（P0.05）,the level of CRP（10.75±1.02）、cTnT（0.01±0.01） and TNF-α（95.86±10.68） of the high-SNP group patient wre lower than CRP（20.76±2.58）、cTnT（0.51±0.07） and TNF-α（149.65±16.78） which was treated before.Conclusion High concentration of sodium nitroprusside showed great therapeutic effect on chronic heart failure.