全身惊厥型癫痫持续状态的临床分析研究

目的探讨全身惊厥型癫痫持续状态(GCSE)的常见病因、诱因、治疗及预后。方法回顾性分析61例GCSE的临床资料、救治过程及预后情况。结果本组GCSE病因有脑外伤、脑血管病、颅内感染、脑肿瘤、毒品戒断、CO中毒、有机磷农药中毒等,原因不明占24.6%。诱发因素有用药不当、发热、酗酒、精神创伤等。本组治愈率68.9%、后遗症发生率9.8%、死亡率16.4%,呼吸、循环衰竭是导致死亡重要因素。结论 GCSE的病因复杂多样,多种因素可诱发GCSE,首要诱发因素是用药不当,故应规范使用抗癫痫药。GCSE应及时采取有效的救治,同时加强病因治疗,迅速控制发作、防止呼吸、循环衰竭是抢救成功的关键。

Objective To discuss the common pathogenesis,inducement,therapy and prognosis of generalized convulsive status epilepticus.Methods The clinical data,therapeutic process,prognosis in 61 cases of GCSE were retrospectively analyzed.Results The pathogeny in the group we researched are cerebral trauma,cerebrovascular disease,intracranial infeion,cerebral tumor,drug withdraw,carbon monoxide intoxication,poisoning of organic phosphorus and so on,unknown aetiology is 24.6%.The inducement include irrational administration of drug,fever,drink,psychic traumas,etc.The cure rate was 68.9%,complication was 9.8%,mortality was 16.4%.Respiration and circulation failure was the important elements causing death.Conclusion The aetiology of GCSE is complicated and diversifi ed,irrational administration of drug is the fi rst importance,so antiepileptics should be applicated standardized.Effective treatment should be taken in time to GCSE,and in the same time,enhancing treatment based on the etiology,controlling quickly,preventing respiration and circulation failure is critical.