内源性高磷血症患儿血清1，25-二羟基胆骨化醇水平变化

Analysis of the level of Serum 1,25-Dihydroxy Cholecalciferol in 30 children with Endogenous Hyperphosphatemia

目的探讨高磷血对1，25-二羟基胆骨化醇（1，25（OH）2D3）水平的影响。方法空腹静脉血，采用OLPUMSAU400，以磷钼酸紫外线法测定血磷，甲基麝香草酚蓝光度法（MTB）测定血钙；以放射免疫方法测定30例高磷血组和30例正常血磷组的1，25（OH）2D3的含量。结果高磷血症组的血磷和钙磷乘积明显高于正常血磷组，两组差异有统计学意义；高磷血症组的血钙略低于正常血磷，但其差异无统计学意义（P〉0．05）；高磷血症组1，25（OH）2D3的含量明显低于正常血磷组，其差异有统计学意义（P〈0．01）。结论高磷血症可抑制1，25（OH）2D3的合成。

Objective To explore the effect of the level of 1,25-Dihydroxy Cholecatciferol in 30 cases of children with endogenous hyperphosphatemia. Methods Using fasting blood and OLPUMS AU400, determination of phosphorus by Phosphomolybdate ultraviolet France, determination of serum calcium by methyl thymol blue speetro- photometry （MTB） colorimetric, Determination of 1,25 （OH）2D3 levels in 30 cases of high-phosphorus blood group and 30 cases of normal serum phosphate group by Ydioimmunoassay. Results The phosphorus and calcium phosphate product in hyperphosphatemia group is significantly higher than the normal serum phosphate group. The difference is statistically significant. The calcium is slightly lower than the normal serum phosphate in hyperphosphatemia group, The difference is not significant（P 〉0.05）. The 1,25 （ OH）2D3 of hyperphosphatemia group is significantly lower than the normal serum phosphate group. The difference is statistically significant （P 〈 0.01 ）. Conclusion Hyperphosphatemia can inhibit the synthesis of 1,25 （OH）2 D3.