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CUEDC1氨基酸保守性分析及抑制TGF-beta/Smad转录活性 被引量：2

Conservative Analysis of CUEDC1 Amino Acid Sequence and CUEDC1 Inhibits Transcriptional Activity of TGF-beta/SMAD
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摘要 为了分析CUEDC1氨基酸保守性和研究CUEDC1蛋白质影响TGF-beta/SMAD信号通路的转录活性,用软件分析比较CUEDC1的氨基酸序列和通过双荧光报告系统测定TGF-beta/SMAD转录活性。结果显示cue结构域在人、小鼠和大鼠之间相似性为100%和过表达CUEDC1能够抑制TGF-beta/SMAD转录活性。 To study the effect of CUEDC1 on the transcriptional activity of TGF-beta /SMAD and conservative analysis of CUEDC1 amino acid sequence.Dual-Luciferase Reporter Assay System was used to evaluate the effect of CUEDC1 on transcriptional activity of TGF-beta /SMAD.CUEDC1 could inhibit TGF-β/SMAD signaling pathway.
作者 李文龙 巩伟丽 魏传宇 王晨辉 穆蕊 方迪峰 陈亮 周涛
机构地区 国家生物医学分析中心
出处 《科学技术与工程》 2010年第13期3057-3060,共4页 Science Technology and Engineering
基金 国家自然科学基金(30872921)资助
关键词 CUEDC1 SMAD TGF-BETA 转录活性 CUEDC1 SMAD TGF-beta transcriptional activity
分类号 Q527 [生物学—生物化学]
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参考文献11

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二级参考文献7

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科学技术与工程
2010年 第13期

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