期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Sr(OTf)_2/H_2O_2催化的3,4-二氢嘧啶酮类药物中间体的合成 被引量：2

Sr(OTf)_2/H_2O_2-catalyzed One-pot Method for Synthesis of Dihydropyrimidiones
下载PDF
导出
摘要 研究了在催化量的Sr(OTf)2/H2O2存在下,卤化苄、β-羰基羧酸酯和脲发生Biginelli缩合反应。"一锅法"高效地得到3,4-二氢嘧啶酮类药物中间体。该反应具有适用范围广、反应条件温和、产物收率高,环境友好,催化剂可回收再用且不失活性等优点,为3,4-二氢嘧啶酮类药物中间体的合成提供了一条全新的理想路线。 A novel and efficient synthesis of dihydropyrimidiones is developed by one-pot condensation of benzyl halohydrocarbon,β-naphthol and 1,3-dicarbonyl compounds in the presence of strontium（II）triflate/hydrogen peroxide as a catalyst in high yields.
作者 唐文渊 蒋华江 庄玉国 洪志 黄国波
机构地区 台州学院医药化工学院
出处 《科学技术与工程》 2010年第14期3534-3538,共5页 Science Technology and Engineering
关键词 Sr(OTf)2/H2O2催化体系 Biginelli缩合反应 一锅法 二氢嘧啶酮类药物中间体 strontium（II）triflate/hydrogen peroxide dihydropyrimidiones one-pot condensation
分类号 TQ463.54 [化学工程—制药化工]
  • 相关文献

参考文献16

  • 1Kappe C O.Biologically active dihydropyrimidones of the Biginelli-type-a literature survey.Eur J Med Chem,2000;35:1043-1052.
  • 2Sadanandam Y S,Shetty M M,Diwan P V.Synthesis and biological evaluation of new 3,4-dihydro-6-methyl-5-N-methyl-carbamoyl-4-(substituted phenyl)-2(1H) pyrimidinones and pyrimidinethiones.Eur J Med Chem,1992; 27:87-92.
  • 3Biginelli P.Aldureides of ethylic acetoacetate and ethylic oxalacetate.Gazz Chim Ital,1893; 23:360-416.
  • 4Hu E H,Sidler D R,Dolling U H.Unprecedented catalytic three component one-pot condensation reaction:an efficient synthesis of 5-alkoxycarbonyl-4-aryl-3,4-dihydropyrimidin-2-(1H)-ones.J Org Chem,1998; 63:3454-3457.
  • 5Wang L,Qian C,Tian H,et al.Lanthanide triflate catalyzed one-pot synthesis of dihydropyrimidin-2(1H)-thiones by a three-component of 1,3-dicarbonyl compounds,aldehyde,and thiourea using a solvent-free Biginelli condensation.Synth Commun,2003; 33:1459-1468.
  • 6Ghosh R,Maiti W,Chakraborty A.In(OTf)3-catalysed one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones.J Mol Cat A:Chem,2004; 217:47-50.
  • 7Maiti G,Kundu P,Guin C.One-pot synthesis of dihydropyrimidinones catalysed by lithium bromide:an improved procedure for the Biginelli reaction.Tetrahedron Lett,2003; 44:2757-2758.
  • 8Reddy C V,Mahesh M,Raju P V K,et al.Zirconium(Ⅳ) chloride catalyzed one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones.Tetrahedron Lett,2002; 43:2657-2659.
  • 9Ramalinga K,Vijayalakshmi P,Kaimal T N B.Bismuth(Ⅲ)-catalyzed synthesis of dihydropyrimidinones:Improved protocol conditions for the Biginelli reaction.Synlett,2001; 863-865.
  • 10Lu J,Bai Y.Catalysis of the Biginelli reaction by ferric and nickel chloride hexahydrates.One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones.Synthesis,2002:466-470.

同被引文献23

引证文献2

二级引证文献11

科学技术与工程
2010年 第14期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部