三七三醇皂苷在预防高血压性脑卒中的实验研究

PTS IN THE PREVENTION OF STROKE IN HYPERTENSIVE EXPERIMENTAL STUDY

目的:探讨三七三醇皂苷对高血压基础上自发性卒中的预防效果。方法:采用易卒中型肾血管性高血压大鼠(RHRSP)120只,随机分为2组,三七三醇皂苷组90只,生理盐水组30只。肾动脉狭窄术后4周始,分别用三七三醇皂苷或生理盐水灌胃每天一次,持续10周。记录出现卒中的大鼠数。肾动脉狭窄术后14周处死所有大鼠,病理检查各组动物脑卒中发生病灶数和面积,并进行比较分析。结果:用药10周期间,三七三醇皂苷组大鼠卒中发生率显著低于生理盐水组(p<0.05)。按血压增高水平分亚组评估,血压低、中度增高亚组大鼠卒中发生率亦低于生理盐水组,血压重度增高组则与生理盐水组无显著差异。各亚组的卒中病灶面积均小于生理盐水组(p<0.05)。结论:三七三醇皂苷无降压作用,但可降低易卒中型肾血管性高血压大鼠的脑卒中发生率,并减轻卒中严重程度。

Objective：To investigate the PTS on the basis of spontaneously hypertensive stroke preventive effect.Methods：Stroke-prone renovascular hypertensive rats（RHRSP） 120 were randomly divided into two groups,PTS group 90 and saline group 30.After 4 weeks of Renal artery stenosics operation,373 alcohol saponin or saline gavage was used respectively,once a day for 10 weeks.Record the number of rats with stroke occurs.All rats with renal artery stenosis were killed after 14 weeks,examine all animals the pathological number and size of lesions in stroke occurrence,and a comparative analysis.Results：The medication for 10 weeks during the PTS incidence of stroke in rats was significantly lower than saline group（p 〈0.05）.According to the level of sub-sub-group of blood pressure assessment,blood pressure,low,moderate subgroups increased incidence of stroke in rats is also lower than normal saline group,increased blood pressure and severe groups and saline group were not significantly different.The sub-group of the stroke lesion area was less than saline group（p 〈0.05）.Conclusion：The PTS no antihypertensive effect,but can reduce stroke-prone renovascular hypertensive rats,the incidence of stroke and reduce stroke severity.