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克隆性基因重排在淋巴瘤诊断中的应用 被引量：14

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摘要 大多数淋巴组织增生性病变通过组织形态学和免疫表型可得出肯定诊断，大约有5％～10％的病例表现复杂，即使做大量的免疫标志可能也难以鉴别其良恶性，免疫球蛋白和T细胞受体（TCR）基因克隆性重排可作为重要的辅助指标协助诊断，其基本原理是淋巴瘤（或其他淋巴细胞性恶性肿瘤）起源于单个恶性转化的淋巴细胞，相同的克隆具有相同的基因重排方式。
作者 周晓燕
机构地区 复旦大学附属肿瘤医院病理科上海医学院肿瘤学系
出处 《中华病理学杂志》 CAS CSCD 北大核心 2010年第5期347-349,共3页 Chinese Journal of Pathology
关键词 克隆性基因重排 协助诊断 淋巴瘤 淋巴细胞性 应用 组织形态学 增生性病变 克隆性重排
分类号 R733.1 [医药卫生—肿瘤]
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参考文献14

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  • 4van Krieken JH,Langerak AW,Macintyre EA,et al.Improved reliability of lymphoma diagnostics via PCR-based clonality testing:report of the BIOMED-2 Concerted Action BHM4-C398-3936.Leukemia,2007,21(2):201-206.
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二级参考文献24

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同被引文献92

引证文献14

二级引证文献46

中华病理学杂志
2010年 第5期

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