外周动静脉同步换血对新生儿机体内环境的影响

Effects of synchronized peripheral arterial-venous exchange transfusion on neonatal internal environment

目的探讨外周动静脉同步换血对新生儿机体内环境的影响及不良反应。方法60例重症黄疸患儿予外周动静脉同步换血治疗。换血过程持续监测经皮血氧饱和度(SpO2)、心率、呼吸、血压等生命体征的变化,在换血前、后分别做血胆红素、血常规、血气分析、血糖及血生化检测,同时观察换血引起的不良反应。结果换血后患儿血清胆红素明显下降(P<0.01),红细胞、血红蛋白、红细胞压积换血后也有提高。而换血前后生命体征、血气分析、血生化各项指标相比差异无统计学意义。结论外周动静脉同步换血能快速降低血清胆红素,对机体内环境影响小。

Objective To investigate the effects of synchronized peripheral arterial-venous exchange transfusion（ET）on neonatal internal environment.Methods The synchronized peripheral arterial-venous ET was performed in 60 neonates with severe hyperbilirubinemia.The vital signs of SpO2,heart rate,blood pressure and respiratory rate were continuously monitored.Blood bilirubin,glucose and biochemistry and blood gas were mearured before and after procedure.Adverse effects were recorded as well.Results Blood bilirubin level was significantly lower after ET than that before（P0.01）.Blood red cell count,hemoglobin and hematocrit level were increased after ET.There were no significant changes in vital signs,blood gas,biochemistry after ET.ConclusionThe synchronized peripheral arterial-venous ET can effectively quickly reduce blood bilirubin level without adverse effect on internal environment in the neonatals with severe hyperbilirubinemia.